Ann and Nancy Wilson

Sisters Ann and Nancy Wilson have been rocking out in the band Heart for decades.

The Afflecks

Actors Ben and younger brother Casey

Beau and Jeff Bridges

The Spears Sisters

Jamie Lynn and older sister Britney

Donny and Marie Osmond

He’s a little bit rock and roll and she’s a little bit country

Sisters Emily and Zooey Deschanel

Actresses Zooey Deschanel (L) and Emily Deschanel in Hollywood. (Photo by Frazer Harrison/Getty Images)

Tiki and Ronde Barber

Former Giants running back Tiki poses at book signing with Tampa Bay Buccaneer brother Ronde. (Photo by Amy Sussman/Getty Images)

The Duffs

Haylie poses with little sis Hilary

The Gyllenhaals

Maggie and brother Jake at the 2010 Academy Awards.

The Simpson Sisters

Singers Ashlee and Jessica Simpson

The Cusacks

Actress Joan and her actor brother John

Julia and Eric Roberts

“Pretty Woman” Julia and her older brother Eric

The Wilson Brothers

Actors Luke and Owen Wilson

The Wahlbergs

Actors Mark and Donnie

The Olsen Twins

Sisters Mary-Kate and Ashley

Oliver and Kate Hudson

Actor Oliver Hudson and his sister Kate. (Photo by Kevin Winter/Getty Images)

The Hilton Sisters

Paris and Nicky

Peyton and Eli Manning

The famous quarterbacks have both won Super Bowls.

Serena & Venus Williams

Tennis players Venus Williams and Serena Williams attend the USTA and Heineken’s 2010 US Open Player Party at Empire Hotel on August 27, 2010 in New York City. (Photo by Jason Kempin/Getty Images)

Shirley MacLaine and Warren Beatty

Shirley and her brother are Hollywood legends

The Arquettes

L to R: Actors Alexis Arquette, Rosanna Arquette, Richmond Arquette, Patricia Arquette and David Arquette

The Baldwin Brothers

L to R: Billy, Stephen, Alec and Daniel

The Jackson Family

Brothers Tito, Jackie, Randy and Marlon Jackson appear onstage with their parents Joe and Katherine, sisters Rebbie, Janet and LaToya

The Kardashian Sisters

(L to R) Kim Kardashian, Khloe Kardashian and Kourtney Kardashian. (Photo by Andy Kropa/Getty Images)

The Wayans

(L-R) Director Damien Dante Wayans, actor Craig Wayans, actor Marlon Wayans, actor Shawn Wayans, actress Kim Wayans and producer Keenan Ivory Wayans.